Comparative Effects of Radon Inhalation According to Mouse Strain and Cisplatin Dose in a Cisplatin-induced Renal Damage Model
Comparative Effects of Radon Inhalation According to Mouse Strain and Cisplatin Dose in a Cisplatin-induced Renal Damage Model
Kaori Sasaoka1, Takahiro Kataoka1, Norie Kanzaki1, Yusuke Kobashi1, Akihiro Sakoda2, Yuu Ishimori2 and Kiyonori Yamaoka1,*
Representative photos of hair condition and scale score in mice. A, indicates the normal hair condition and scale score of control mice; B, represents each score of hair condition; C, each score of scale score.
Effects of radon inhalation on the body condition score (BCS), scale score, and hair condition score in C57BL/6J and BALB/c mice with CDDP-induced renal injury. ||| P < 0.001 compares the effects of the radon inhalation group at 2000 Bq/m3 vs. the sham group in the C57BL/6J strain. +++P < 0.001 indicates the comparison of the radon inhalation group at 2000 Bq/m3 vs. the sham in the BALB/c strain. N.D. means “not detected”. Photographs of mice show the methods for measuring the BCS, scale score, and hair condition score.
Effects of radon inhalation on the body condition score (BCS) and hair condition score in BALB/c mice with 15 mg/kg CDDP-induced renal injury. |||P < 0.001 indicates the comparison of the group treated with 15 mg/kg CDDP after radon inhalation at 2000 Bq/m3 vs. the sham. N.D. means “not detected.” Pictures of mice indicate the method of measuring the BCS and hair condition score.
Effects of radon inhalation on the influence of 20 mg/kg CDDP administration in body weight, the rate of body weight loss, absolute and relative kidney weight, and urine specific gravity in C57BL/6J and BALB/c mice with CDDP-induced renal injury. ¶¶¶P < 0.001 compares the data of the treatment groups vs. the control measured at 72 h after CDDP administration in the C57BL/6J strain; the sham group received 20 mg/kg CDDP only with air inhalation. †††P < 0.001 indicates the comparison of the treatment groups vs. the control in the BALB/c strain at 72 h after CDDP administration. $P < 0.05, $$P < 0.01, $$$P < 0.001 indicate comparisons of the treatment group vs. the control in the C57BL/6J strain.# P < 0.05, ## P < 0.01, ### P < 0.001 indicate the treatment groups vs. the control in the BALB/c strain. §P < 0.05 and §§ P < 0.01 compare data at 72 h after CDDP administration vs. before radon inhalation in the C57BL/6J strain. * P < 0.05, ** P < 0.01, and *** P < 0.001 compare the data at 72 h after CDDP administration in the treatment groups vs. before radon inhalation in the BALB/c strain. +P < 0.05, ++P < 0.01, and +++P < 0.001 indicate the CDDP and radon inhalation groups vs. the sham in the BALB/c strain. :P < 0.05 indicates the CDDP and 1000 Bq/m3 inhalation group vs. the sham in the BALB/c strain.
Effects of radon inhalation on the 15 mg/kg CDDP-induced renal injury clinical signs, body weight, the rate of body weight loss, absolute and relative kidney weight, and urine specific gravity in BALB/c mice. #P < 0.05, ##P < 0.01, and ###P < 0.001 indicate the radon inhalation groups vs. the control. |P < 0.05 indicates the data at 72 h after CDDP administration with 2000 Bq/m3 radon inhalation vs. the sham (15 mg/kg CDDP only with air inhalation). +P < 0.05 indicates CDDP administration after 2000 Bq/m3 radon inhalation vs. the sham.
Effects of radon inhalation on the influence of 20 mg/kg CDDP administration on A) the serum creatinine level, and B) antioxidant-related substances in C57BL/6J and BALB/c mice with CDDP-induced renal injury. $P < 0.05 and $$$P < 0.001 indicate the treatment groups vs. the control in the C57BL/6J strain. The sham group represents the group administered with 20 mg/kg CDDP only with air inhalation. #P < 0.05, ## P < 0.01, and ### P < 0.001 indicate the treatment groups vs. the control in the BALB/c strain. +P < 0.05 and +++P < 0.001 indicate the radon inhalation groups vs. the sham in the BALB/c strain.
Effects of radon inhalation on the changes in A) serum creatinine level and B) antioxidant-related substances caused by 15 mg/kg CDDP in BALB/c mice with CDDP-induced renal injury. ##P < 0.01 indicates the treatment groups vs. the control. The sham group was treated with 15 mg/kg CDDP only with air inhalation. |P < 0.05 and |||P < 0.001 indicate the radon inhalation groups vs. the sham.
