Changes in Kisspeptin, Growth and Thyroid Hormones in Thalassemic Patients of Pubertal Age Group
Changes in Kisspeptin, Growth and Thyroid Hormones in Thalassemic Patients of Pubertal Age Group
Shazia Ali, Hizb Ullah and Sarwat Jahan*
ABSTRACT
Beta thalassemia syndrome are a group of hereditary blood disorders in which or absent beta globin chain synthesis, results in reduced Hemoglobin, decreased RBC production and anemia. Total 300 individuals were divided into 4 groups according to age and gender i.e ≤13 years females, >13 years females, ≤13 years and >13 years males. Height in centimeter, weight in kilogram was measured to calculate BMIKg/m2. Serum ferritin (ng/mL) and hemoglobin (gm/dl) alongwith hormonal assay of GH (ng/mL), T3 (ng/mL), T4 (µg/dL), TSH (μIU/mL), and kisspeptin (ng/ml) was done. BMI and hemoglobin were significantly reduced (P<0.001), while serum ferritin were significantly increased (P<0.001) in all four thalassemic groups on comparison with control. Kisspeptin levels were significantly reduced in ≤13 years female (P<0.001). While significantly high levels were observed in >13 years of male (P<0.01). T3 levels were significantly increased in both thalassemic groups of female (P<0.01). While T4 levels were significantly reduced in ≤13 years of male alongwith significantly reduced (P<0.05) TSH levels. In >13 years male significantly increased (P<0.01) TSH levels were obtained. Growth hormone levels were significantly reduced (P<0.001) in both male and female thalassemic groups of ≤13 years. While significantly raised (P<0.001) hormone levels were observed in male and female thalassemic groups of >13 years. In >13 thalassemic female T3 had a negative correlation (P<0.05) with BMI and hemoglobin, while a positive correlation (P<0.001) of T3 with hemoglobin was observed in thalassemic male of ≤13 years. In >13 years male T3 had a positive correlation (P<0.05) with kisspeptin. T4 in all four thalassemic groups had a significant positive correlation with hemoglobin (P<0.05). TSH in >13 years female had a significant positive correlation with BMI, ferritin and hemoglobin (P<0.001). Results revealed that hypothalamic pituitary axis had proper production, other factors miught be involved in delaying the growth spurt.
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June 2017
Vol. 49, Iss. 3, Pages 761-1149
