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Bioinformatic Analysis of the Possible Mechanism of TOP2A Expression in the Development of Liver Cancer

Bioinformatic Analysis of the Possible Mechanism of TOP2A Expression in the Development of Liver Cancer

Man Wang1 and Fengmei Yang2*

1Department of Outpatient, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China
2Department of Obstetrics and Gynecology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China
 
*      Corresponding author: 29256175@qq.com

Fig. 1.

The correlation between gene expression and clinical stages, gene methylation levels, and expression levels of TOP2A genes analyzed by different tools in tumor and normal tissues. A: GEPIA2; B: TIMER; C: Ualcan; D: The correlation between gene expression and clinical stages; E: methylation level.

Fig. 2.

Analysis of the correlation between immune cell infiltration and TOP2A expression (2A), the relationship between immune cell infiltration with different gene expression levels and prognosis (2B).

Fig. 3.

TIMER and GEPIA analyzed the correlation between gene expression and surface markers of immune cell.

Fig. 4.

Analysis of the correlation between TOP2A expression and clinical prognostic. A: OS; B: DFS; C: Survival probability.

Fig. 5.

Univariate and Multivariate analysis of prognosis in patients with liver cancer. A: OS; B: DSS; C: PFI.

Fig. 6.

Protein-protein Interaction network of TOP2A related proteins.

Fig. 7.

Expression of TOP2A protein in liver cancer tissue and normal tissue.

Pakistan Journal of Zoology

December

Vol. 54, Iss. 6, Pages 2501-3000

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