Assessing Analgesia and Motor Block Scores in Male Dogs: The Impact of Single vs. Repeated Dose Lumbosacral Liposomal Lidocaine
Assessing Analgesia and Motor Block Scores in Male Dogs: The Impact of Single vs. Repeated Dose Lumbosacral Liposomal Lidocaine
Sena’a M. Hussein1,2, Raffal A. Omar3*
ABSTRACT
In recent medical advancements, there has been growing interest in utilizing liposomes, which are lipid-based vesicles, to enhance the targeted delivery and prolonged release of local anesthetics. The purpose of this study was to assessment the effect of single and repeated lumbosacral injection of liposome carrying lidocaine in comparison with lidocaine hydrochloride. A total of 24 male local breed dogs were divided randomly into the lidocaine group that received 4.5 mg/Kg of 2% lidocaine and liposome group which received the same dose of lidocaine carried by liposome. Pinprick and spinal reflex tests were evaluated each minute for the first five minutes following lumbosacral injection and then every five minutes until the sensory blockade disappeared. Motor activities were constantly monitored and evaluated every 30 seconds. Clinical evaluation of analgesia and motor blocks after injection revealed a complete analgesia and there was no response to deep muscle pricks lasting for (120) / minutes starting after 15 minute from lumbosacral injection while in repeated dose last for (180) / minutes after 15 minutes from injection of liposomal lidocaine. Lidocaine single dose group it lasting for (60) / minutes after 20 minute from lumbosacral injection while and in repeated dose last for (84) / minutes after 20 minutes from injection. Motor score showed a complete muscle relaxation which was strong and lasting for (49) / minutes from 15 minute after lumbosacral injection while in repeated dose last for (101) / minutes from 20 minutes from injection of liposomal lidocaine. Lidocaine single dose concerning complete muscle relaxation score lasted for (25) / minutes from 20 minute after lumbosacral injection . In repeated dose last for (53) / minutes from 20 minutes from injection. Nerve functions scores revealed a significant different injections between liposomal lidocaine groups and lidocaine groups. In motor block after injection, there was no significant differences were observed between the two groups during the study periods. Analgesia after recovery clinical evaluation show significantly different between groups, the motor after recovery recorded in significantly different. The conclusion, Lumbosacral liposomal lidocaine injection demonstrates safety, rapid induction, and excellent analgesia, ensuring smooth recoveries suitable for surgery without complications.
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