Antimicrobial efficacy of combination of lincomycin and spiramycin (Lispiracin™) as systemic dry cow therapy for controlling bovine mastitis
Antimicrobial efficacy of combination of lincomycin and spiramycin (Lispiracin™) as systemic dry cow therapy for controlling bovine mastitis
Antimicrobial efficacy of combination of lincomycin and spiramycin (Lispiracin™) as systemic dry cow therapy for controlling bovine mastitis
Hafiz Muhammad Umer Qaisar1, Tanveer Ahmad2, Muhammad Rizwan3*, Muhammad Saqib1
ABSTRACT
To determine the efficacy of combination of lincomycin and spiramycin
(Lispiracin™) for controlling bovine mastitis through systemic dry period therapy,
present study was designed. A total of 20 dry pregnant cows were selected
randomly at the end of lactation and divided into two equal G1 and G2 groups.
Group G1 was treated with lincomycin@ 5mg/kg (IM) and spiramycin@ 10 mg/kg
(IM) (Inj. lispiracin®) at end of lactation and at 14th day pre calving while group G2
was kept as control. Samples of milk were collected aseptically at dry off and at
day 14th post-calving. The efficacy of treatment was determined through
prevalence of mastitis (sub-clinical and clinical) before and after parturition and
bacteriological cure rate. Quarter and animal wise prevalence of both clinical and
sub-clinical mastitis after systemic dry cow therapy with lispiracin™ group (G1) was
lower than control group (G2). This was evaluated through Surf Field Mastitis Test,
Somatic cell count, isolation, identification and purification of microbiological
cultures. The mean score of surf field mastitis test of G1 group before treatment
and at day 14thpost calving was significantly different (p<0.05) as compared to G2
group Somatic Cell Count was significantly reduced from 8.0 at dry off to 3.50
(P<0.05) after day14th post calving in lispiracin™ group. Quarter wise prevalence
(%) of clinical mastitis in G1 group was lower than G2 group. The cure rate of
infected quarters at day 14th post calving was 86.6% (p< 0.01) with lispiracin™
treated group than that of control group which was 11.11%.It was concluded that
systemic dry period therapy especially with combination of lincomycin and
spiramycin (lispiracin™) helped in controlling bovine Mastitis.
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