Anti-Stress Activity of Oviductus Ranae in Mice with Acute Stress Based on Network Pharmacology
Anti-Stress Activity of Oviductus Ranae in Mice with Acute Stress Based on Network Pharmacology
Zhe Lin1, Yumo Li1, Yuchen Wang1, Yuechen Li1, Ke Pei1, Guangfu Lv2, He Lin1* and Zhun Yu3*
Fig. 1.
Functional enrichment analysis of the therapeutic targets of OR against stress. (A) The top 20 GO-BP terms; (B) The top 20 KEGG pathway terms.
The circle size represents the count of therapeutic targets enriched in a certain pathway; the associated genes (%) means the percentage of target genes to the background genes of a certain pathway.
Fig. 2.
Effect of OR on the forced swimming endurance test (A) and anoxic tolerance test (B) in mice.
* p <0.05 compared with the control.
Fig. 3.
The effect of OR on the changes of monoamine neurotransmitters in brain tissue under stress state.
5-HIAA, 5-hydroxyindoleacetic acid (A); 5-HT, 5-hydroxytryptamine (B); DA, dopamine (C); NE, norepinephrine (D). * p<0.05 or ** p<0.01 compared with the control.
Fig. 4.
Effects of OR on phosphorylation levels of p38 in the brain tissues by western blot.
June 2023
Vol. 55, Iss. 3, Pages 1003-1500
