The adequate amounts of chromium (Cr) enhance the endocrine system and metabolism but its ridiculous use and bio-accumulation through food chain might be causing oxidative stress. That study was conducted to evaluate the protective effects of Jambul (Syzygium cumini) against Cr induced reno-hepatic anomalies. Male albino mice (Mus musculus) were equally divided (n=10) as C; control, Cr-treatedandCr-JgroupsreceivingCr+6 in the form of potassium dichromate (K2Cr2O7) 50ppm for 10days ad-libitum while Cr-J group additionally given 0.25ml/12h Jambul Fruit Extract (JFE) for next 5days by oral gavage. On the 16th day blood, liver and kidney were collected for biochemical and histopathological analysis.Cr+6 treated group showed severe histological changes like necrosis, cirrhosis and dehydration in liver evident by significant elevation of Serum Glutamic Pyruvic Transaminase (SGPT), Serum Glutamic Oxaloacetic Transaminase (SGOT), Alkaline Phosphatase (ALP), total protein, bilirubin, globulin, creatine and uric acid along with reduction of SGOT/SGPT, Blood Urea Nitrogen (BUN), urea and albumin as compared to control. Treatments with JFE after Cr+6 exposures significantly improved the hepatic and renal functional profiles possibly by partial liver rehabilitation and regeneration. The JFE significantly recovered the histopathological alterations in reno-hepatic tissue by free radicals scavenging and metal chelating abilities due to presence of anthocyanin, flavonoids and β-sitosterol. The JFE’sprotective effects against heavy metals environmental toxicants especially Cr+6 is novel and cheapest; that should be sponsored for ethno-medicinal purpose.