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The Inhibition of Cell Proliferation of Bile Duct Scar Fibroblasts in Miniature Pigs by 5-fluorouracil and its Mechanism

The Inhibition of Cell Proliferation of Bile Duct Scar Fibroblasts in Miniature Pigs by 5-fluorouracil and its Mechanism

Shikang Deng1,2, Yan Jin2, Jing Xu2, Xiufang Zhu2, Pinghai Hu2, Jiao Li2, Li Zhang2 and Jianzhong Tang2,*

1Medical Faculty, Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, 650504, China
2Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Kunming University of Science and Technology The First People’s Hospital of Yunnan Province, 650032, China

*     Corresponding author: virwm3@163.com

Fig. 1.

The effect of 5-FU on the OD value of bile duct scar fibroblasts in miniature pigs (n=3). Compared with group A, aP <0.05; compared with group B, bP <0.05; compared with group C, cP <0.05; and compared with group D, dP <0.05.

Fig. 2.

The effect of 5-FU on the expression levels of TGF-β1, cyclinD1, and CDK4 proteins in miniature pig bile duct scar fibroblasts (n=3).Compared with group A, aP <0.05; compared with group B, bP <0.05; compared with group C, cP <0.05; and compared with group D, dP <0.05.

Fig. 3.

The effect of 5-FU on the expression levels of TGF-β1, cyclinD1, and CDK4 mRNA in miniature pig bile duct scar fibroblasts (n=3). Compared with group A, aP <0.05; compared with group B, bP <0.05; compared with group C, cP <0.05; and compared with group D, dP <0.05.

Pakistan Journal of Zoology

April

Vol. 53, Iss. 2, Pages 401-800

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