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HBA1C as a Dual Marker for the Detection of Lipid Profile and Cardiovascular Disease in Type-ΙI Diabetic Subjects

HBA1C as a Dual Marker for the Detection of Lipid Profile and Cardiovascular Disease in Type-ΙI Diabetic Subjects

Ahmad Sadiq1, Muzafar Shah2*, Habib Ullah1, Irfan Ali1, Amir Alam3
Navid Jalil1 and Muhammad Khan3

1Department of Zoology, Government College Daggar Buner, University of Swat, Pakistan
2Centre for Animal Sciences and Fisheries, University of Swat, Pakistan
3Department of Zoology, Hazara University, Mansehra, Pakistan

*      Corresponding author: muzafar@uswat.edu.pk

ABSTRACT

Diabetic patients are deliberated to be at greater risk of hypertension and lipid abnormalities, which are the main cause of cardiovascular diseases (CVD). The present work revealed the role of glycated hemoglobin (HbA1c) for the detection of lipid profile and CVD. In recent study 108 (56 males and 52 female) type 2 diabetes (T2DM) subjects were diagnosed at Hayatabad Medical Complex (HMC) Peshawar and private diabetic clinic “Khattak Medical Centre” (KMC), Dabgari Garden Peshawar, Khyber Pakhtunkhwa, Pakistan. The normal or control group consists of twenty (9 females and 11 males) people having no history of diabetes mellitus, hypertension and cardiovascular disease. Glycated hemoglobin HbA1c, random blood sugar (RBS) triglycerides (TG) total cholesterol (TC) systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly higher in patients (p<0.05) than normal or controlled. In patients with low density lipoprotein (LDL), high density lipoprotein (HDL) and body mass index (BMI) were found to be significantly lower (p > 0.05) than normal or control. Gender-based analysis has shown that HbA1c, RBS, DBP and SBP in male patients have significantly higher (p<0.05) than female. But in female patients the TC, TG and BMI are insignificantly higher (p<0.05) compared to male. High density lipoprotein (HDL) was found same in both male and female. Moreover, patients with HbA1c > 7 have 26.66% stroke, 4.44% angina, 2.22% ischemic heart disease and 27.77% micro vascular complications.
 

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Pakistan Journal of Zoology

April

Vol. 53, Iss. 2, Pages 401-800

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