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Expression Analysis of Oxidative Stress Induced Genes in Liver and Heart Tissues in Response to Doxorubicin

Expression Analysis of Oxidative Stress Induced Genes in Liver and Heart Tissues in Response to Doxorubicin

Uzma Jabeen1, Irfan Khan2, Nadia Naeem2, Asmat Salim2,* and Waseem Ahmed1

1Department of Biochemistry, and Department of Biotechnology Federal Urdu University of Arts Science and Technology, Gulshan-e-Iqbal Campus, Karachi-75300
2Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270

*      Corresponding author: asmat.salim@iccs.edu

 

Fig. 1.

Bar diagram and representing gels showing RT-PCR gene expression analysis of the oxidative stress genes, NAD(P)H quinone dehydrogenase 1 (Nqo1), Glutathione peroxidase (Gpx1) and Isocitrate dehydrogenase-1 (Idh1) in the heart tissue after doxorubicin treatment in SD rats. Data are expressed as the means ± standard error of the mean as analyzed by Student’s t-test; the level of significance is p< 0.05.

Fig. 2.

Bar diagram and representing gels showing RT-PCR gene expression analysis of the oxidative stress genes, NAD(P)H quinone dehydrogenase 1 (Nqo1), Glutathione peroxidase (Gpx1) and Isocitrate dehydrogenase-1 (Idh1) in the liver tissue after doxorubicin treatment in SD rats. Data are expressed as the means ± standard error of the mean as analyzed by Student’s t-test; the level of significance is p< 0.05.

Pakistan Journal of Zoology

October

Vol. 51, Iss. 5, Pages 1599-1997

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