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Evaluation of Anxiolytic Activity of Pulsatilla nigricans L. in Wistar Rats by using Elevated Plus Maze and Hole Board Paradigms

Evaluation of Anxiolytic Activity of Pulsatilla nigricans L. in Wistar Rats by using Elevated Plus Maze and Hole Board Paradigms

Rafia Sadaf1, Ishrat Younus2*, Sidra Maqbool2, Talha Bin Fayyaz3Sarah Jameel Khan1, Sidra Siddique1 and Rida Fatima1

1Faculty of Pharmacy, SBB Dewan University, Karachi 
2Faculty of Pharmacy, Hamdard University, Madinat al-Hikmah, Muhammad Bin Qasim Avenue, Karachi
3Department of Pharmacology, Faculty of Pharmacy, Ziauddin University, Karachi

*      Corresponding author: ishratyounas@gmail.com

ABSTRACT

Pulsatilla nigricans Linn has traditionally been used in various disorders related to both male and female and proves a great remedy for ovaralgia, ovaritis, epididymitis, orchitis nervousness, sadness, mild restlessness and mental disorder. This investigation is designed to evaluate acute toxicity and anti-anxiety activity of ethanol extract of Pulsatilla nigricans leaves. The acute oral toxicity shows that, plant extract up to 5000 mg/kg produces no signs and symptoms related to toxicity and also no mortality was observed. Antianxiety activity of Pulsatilla nigricans was examined by using elevated plus-maze paradigm and hole-board paradigm in rats at two different doses i.e. 250 and 500 mg/kg, and significant anxiolytic effects were observed as compare to control.
 

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Pakistan Journal of Zoology

June

Vol. 52, Iss. 3, Pages 825-1224

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