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Concentration Dependent Functions of FGF10 in Angiogenesis and Axon Guidance

Concentration Dependent Functions of FGF10 in Angiogenesis and Axon Guidance

Fang Liu*

School of Basic Medical Sciences, Medical college of Nanchang University, Nanchang, Jiangxi 330006, PR China.

*      Corresponding author: fangliuncueducn@126.com

ABSTRACT

Previous studies suggest FGF10, which is expressed in the ventral hypothalamus, plays important roles in axon guidance and in vasculature guidance of the developing hypothalamus. Here, using ex vivo analyses in chick, we show that FGF10 exerts concentration dependent functions in angiogenesis and hypothalamic axon guidance. At lower concentration of 100ng/ml, FGF10 promotes angiogenesis in chorioallantoic membrane endothelial capillaries (CAMs), but FGF10 does not alter the endothelial growth significantly at higher concentration (500ng/ml, P>0.05). Simultaneously, FGF10 exerts a graded action, at lower concentration FGF10 attracts both magnocellular and parvocellular axons; but at higher concentration, FGF10 repels parvocellular TH+ (tyrosine hydroxylase) axons, and attracts magnocelluar vasopressin+ axons in the hypothalamus.
 

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Pakistan Journal of Zoology

October

Vol. 52, Iss. 5, Pages 1631-2026

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