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Clinical Trends of Hepatic and Renal Profile in Hyperthyroid subjects of Lahore, Pakistan

Clinical Trends of Hepatic and Renal Profile in Hyperthyroid subjects of Lahore, Pakistan

Muhammad Amir Iqbal1, Nabila Roohi1*, Ahmad Qureshy2


1Department of Zoology, University of the Punjab, Quaid-i-Azam Campus, Lahore- 54590, Pakistan
2Department of Nuclear Medicine, Institute of Nuclear Medicine and Oncology, Lahore, Pakistan

Corresponding author: Nabila Roohi



Abstract | Present study was planned to evaluate the alterations in renal and hepatic profile induced by overt hyperthyroidism as well as its subclinical form. A total of 179 subjects comprising both genders and fulfiling the exclusion and inclusion criteria were recruited for this prospective investigation. Sixty healthy controls, thirty four subclinical, fifty overt hyperthyroid and thirty five follow-up subjects having 3 months of anti-thyroid therapy were recruited. Commercially available diagnostic kits were used to determine the serum levels of FT4, FT3, TSH, Creatinine, AST and ALT. Prominent reduction (P<0.001) of creatinine was observed in overt hyperthyroid state, when compared with controls. However, significant (P<0.05) improvement was noticed in it in post treatment group. Pronounced elevation (P<0.001) of ALT was observed in overt state when compared with controls. Subclinical subjects also manifested significant (P<0.05) up regulation, whereas, pronounced reduction (P<0.01) was observed in ALT in post therapeutic condition. Prominent elevation (P<0.001) of AST in both overt as well as subclinical thyroid states have been observed when compared with healthy controls. Whereas, significant reduction (P<0.05) of AST was observed in post treatment group. Conclusively, hyperthyroid conditions markedly influence normal hepatic and renal function, whereas, treatments achieving euthyroid state after anti-thyroid therapy also influence these deviations.

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Punjab University Journal of Zoology


Vol. 37, Iss. 2, pp. 93-182


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