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Antihyperlipidemic Effects of Methanol Extract of Seeds of Citrullus lanatus in Hyperlipidemic Rats

Antihyperlipidemic Effects of Methanol Extract of Seeds of Citrullus lanatus in Hyperlipidemic Rats

Abdullah Abdo Albegali1, Tayyaba Aftab1, Atiq-ur-Rehman1*, Amir Rashid1 and Mayada Mohammad1,2

1Faculty of Pharmacy, The University of Lahore, Defence Road Campus, Lahore
2Institute of Pharmaceutical Sciences, Riphah International University, Lahore

*      Corresponding author: atiqurrehman10@gmail.com

Fig. 1.

Histopathalogical changes in liver of animals induced by Triton X-100. Haematoxylin and Eosin (H and E) ×100. A: normal configurtion of liver. B: untreated Triton X-100 induced hyperlipidaemia rats having severe congestion of hepatic blood vessels (arrows). C: Simvastatin treated rats with mild fatty changes in hepatocytes. D: C. lanatus seeds treated rats having mild congestion of hepatic blood vessels.

Fig. 2.

Effect of methanol extract of the plant seeds on histopathalogical changes in transverse section of hearts of rats induced by Triton X-100. A: normal configuration of heart muscle and coronary vessels. B: accumulation of lipid particles (black arrow) and severe congestion of blood coronary vessels (blue arrow). C: cardiac muscle fibres had vacuolation of lipids droplets (blue arrow) and mild congestion of coronary blood vessels (black arrow). D: mild congestion of blood coronary vessels with no hyperlipidaemia condition.

Pakistan Journal of Zoology

February

Vol. 54, Iss. 1, Pages 1-501

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