Advances in Animal and Veterinary Sciences
Recent Advances in Immunotherapy for the Treatment of Cancer
Namrata Acharya, Dhruv Gohel, Vinod Kuberkar, Senthilkumar Natesan*
Western Range Biopharmaceuticals Pvt Ltd, Cluster Innovation Centre, Genome Research Centre, Maharaja Sayajirao University of Baroda, Vadodara, Gujarat 390 002, India.
*Correspondence | Senthilkumar Natesan, Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India; Email: senthil.natesan@wrbio.com
Abstract
Immunotherapy based approaches to modulate the body’s own immune defense mechanism to fight cancer is gaining momentum due to its successful application for treating different types of cancers recently. There are four major types of immunotherapy approaches including nonspecific immunotherapy using immune-modulatory molecules, monoclonal antibody therapy, vaccines, and cellular immunotherapy. The use of antibodies for treating cancers has been well established there are about dozen antibodies currently available in clinical practice for the treatment of various cancers. Approval of Dendritic cell based therapy by regulatory authorities has led to the recognition of immune cells as drug for treatment of clinical disease. Other modes of immune cell based therapies including Natural killer cells and T cells are also under various stages of development. This review is aimed to provide an overview of different modes of immunotherapy and its application in human and animals.
Keywords | Immunotherapy, Dendritic cell, NK cells, Monoclonal antibodies, Cancer
