Muhammad Naeem1, Bushra Sadia1,2,*, Faisal Saeed Awan1and Muhammad Anjum Zia3
Ghulam Akbar1*, Muhammad Anjum Zia1, Ali Ahmad2, Neha Arooj1 and Shahneela Nusrat1
...ong fibrinolytic enzymes streptokinase (SK) is commonly used in the world to cure heart diseases because its low cost and efficacy. It’s a microbial origin enzyme produced especially by Streptococcus bacterial spp. Therefore, it is antigenic in nature due to microbial source which restricts its use. However, it is necessary to truncate antigenic regions present in the SK gene for the removal of streptokinase antigenici...
Ghulam Akbar1*, Muhammad Anjum Zia1, Amer Jamil1 and Faiz Ahmad Joyia2
...eing used for industrial streptokinase production. It has 414 amino acids globular chain with 47000 D molecular weight. The fibrinolytic drug is comparatively cheap as compared to all other fibrinolytic drugs. It is the drug of choice in all low income nations and developing countries. The mortality rate with cardiovascular diseases is 85% in less developed countries and 75% prevalence is in women. The wild and mutant strains of Streptococcus mutans were used ...
Saad Tahir, Nadeem Ahmed*, Mohsin Ahmad Khan, Muhammad Akram, Rabia Abbas and Kausar Malik
...n blotting by using anti-streptokinase antibodies. Clot lysis assay was used to estimate the biological activity of HSA-SK. For half-life estimation, proteolytic and thermal stability of HSA-SK was also checked....
