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Toxicity of Iron-Oxide Nano-Particles on the Hematology of Cyprinus carpio

Toxicity of Iron-Oxide Nano-Particles on the Hematology of Cyprinus carpio

Khalid Javed Iqbal1, Irfan Baboo2*, Arshad Javid3, Noor Khan4, Hamid Majeed5, Azra Anwer1, Zahid Farooq2, Muhammad Altaf6 and Moazam Jalees7

1Department of Zoology, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
2Department of Zoology, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan
3Department of Wildlife and Ecology, University of Veterinary and Animal Sciences, Lahore
4Department of Fisheries and Aquaculture, University of Veterinary and Animal Sciences, Lahore, Pakistan
5Department of Food Science and Technology, Cholistan University of Veterinary and Animal Sciences Bahawalpur, Pakistan
6Department of Forestry, Range and Wildlife Management, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
7Department of Applied Microbiology, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan
 
* Corresponding author: irfan@cuvas.edu.pk

ABSTRACT

Owing to growing exploration in nanotechnology, nano-particles application in various fields of industries and medicine is growing. However, limited study is available on their toxicological impacts which can adversely affect the organism’s health and their environment. Current research was designed to study the possible toxicity of iron oxide nano-particles on common carp, C. carpio after exposure period of 96 hours by the analysis of their haematological parameters. Fish were segregated into three groups (10fish/treatment). The iron oxide nano-particles at 0.25g/l doze were administered orally to treatment T1 and intravenously from caudal vein of fish to treatment T2. After 96h of exposure period, the blood was collected from fishes by the caudal vein puncture method into tubes containing anticoagulants EDTA and transferred immediately to the laboratory for the assessment of their blood profile. There was recorded no mortality after 96h of exposure period. IONPs significantly affected the counts of WBCs, Hb, MCH and MCHC of experimental and control groups. The analysis of blood profile demonstrated that haematological parameters; the number of WBCs and Hb were increased in T1 and decreased in T2 in relation to T0. The counts of RBCs, HCT, MCV and PLT were found to be increased in both experimental groups as compared to control one. It is inferred from current results that IONPs have toxic effect on the haematology of C. carpio. Moreover, oral route of administering IONPs was found to be more toxic than intravenous one. Present study can be beneficial for the safety of aquatic environment and management of aquatic toxicity.

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Pakistan Journal of Zoology

December

Vol. 54, Iss. 6, Pages 2501-3000

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