Therapeutic Effect of Epigallocatechin-3-Gallate and Quercetin on Renal Stone Formation in Rats
Youfang Li1, Xu Li2, Shaik Althaf Hussain3, Jayasimha Rayalu Daddam4 and Zhigang Chen5*
1Department of Urology Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 714000, China.
2Department of Urology, Eighth People’s Hospital of Qingdao, Qingdao, Shandong Province, 266100, China.
3Department of Zoology, College of Science, King Saud University, P.O. Box - 2454, Riyadh 11451, Saudi Arabia.
4Department of animal sciences, Michigan state university, United states.
5Department of Urology, Affiliated Tumor Hospital of Nantong University and Nantong Tumor Hospital,Tongzhou, 226361, China.
Fig. 1.
Feefect of EGCG and quercitive on the various urine parameters (urea, creatimine Ca++, Uric acid, P Na+, K+, Cl-) in male albino rats. Group I: normal control group; Group II: lithiatic and 1% Tween 80; Group III: allopurinol; Group IV: EGCG; Group V: quercetin; Group VI: EGCG and quercetin. All the values are expressed as mean±SEM of 6 animals. * In the data indicates significance comparison with the control group and # for comparison with the diseased group, * or # p<005, ** or ## p<0.01, *** or ### p<0.001, **** or #### p<0.0001.
Fig. 2.
Effect of EGCG and quercition on the various seral parameters (serum urea, serum creatinine, serum Ca++, serum uric acid, serum phosphorus, serum Na+, serum K+, serum Cl-) on different treatment of the male albino rats.
For details of various groups and statistical details, see Figure 1.
Fig. 3.
Effect of EGCH and quercition on histopathology of the male albino rats kindney. For details of various groups and statistical details, see Figure 1.
Fig. 4.
Effect of EGCH and quercition on tissue antioxidant activity in the male albino rats.
For details of various groups and statistical details, see Figure 1.
Fig. 5.
Effect of EGCH and quercition on tissue expression of miR-21 in the male albino rats.
For details of various groups and statistical details, see Figure 1.
