The Role of Alpha Lipoic Acid and Tempol Against Liver Injury after Acetaminophen Subacute Exposure in Mice
Suhad Mohmmed Alrobyrai1 , Falah Muosa Al-Rekabi2*
1College of Veterinary Medicine, Iraq; 2University of Baghdad College of Veterinary Medicine Department of Physiology, Biochemistry and Pharmacology, Iraq.
*Correspondence | Falah Muosa Al-Rekabi, University of Baghdad College of Veterinary Medicine Department of Physiology, Biochemistry and Pharmacology, Iraq; Email:
[email protected]
Figure 1:
The effect of orally administration APAP, Tempol, and Lipoic Acid for 30 days on body weight/g of male mice. Data= Mean±SEM, A-D significant (P < 0.05) differences between groups, a-c significant (P < 0.05) differences within groups, LSD of interaction=2.529
Figure 2:
The effect of orally administration APAP, Tempol and Lipoic Acid for 30 days on the serum activity of ALT (U/L) in experimental groups. Mean ± SEM, A-D significant (P <0.05) differences between groups, a-b significant (P <0.05) differences within groups, LSD of interaction=40.82.
Figure 3:
The effect of orally administration APAP, Tempol, and Lipoic Acid for 30 days on the GGT (U/L) in the experimental group. Mean ± SEM, A-D significant (P <0.05) differences between groups, a-b significant (P <0.05) differences within groups, LSD of interaction= 2.714.
Figure 4:
The effect of orally administration APAP, Tempol, and Lipoic Acid for 30 days on the PT/ sec in the Experimental group. Mean±SEM, A-D significant (P <0.05) differences between groups, a-b significant (P <0.05) differences within groups, LSD of interaction= 8.289.
Figure 5:
The effect of orally administration APAP, Tempol, and Lipoic Acid for 30 days on the INR in the experimental groups. Mean ± SEM, A-D significant (P <0.05) differences between groups, a-b significant (P <0.05) differences within groups, LSD of interaction= 7.175.
Figure 6:
Liver section of mice of C+ve group shows dilated central vein (C.V) with moderate mononuclear cell infiltration (lymphocytes and macrophages) with marked centrelobular necrosis (coagulative N.) × 40H and E stain.
Figure 7:
Liver section of mice treated by APAP 700 mg/kgBW and Tempol 20 mg/kgBW orally for one month (G3)shows severe mononuclear cell infiltration) lymphocytes and macrophages (with marked necrotic hepatocytes (coagulative N.)×40 H and E stain.
Figure 8:
Liver section of mice treated by APAP 700 mg/kgBW and alpha lipolic acid 20 mg/kgBW orally for 30 days (G4) shows central vein (C.V) with moderate mononuclear cell infiltration and mild centrelobular necrosis (coagulative N.) × 40H and E stain.
Figure 9:
Liver section of mice treated by APAP 700 mg/kgBW and Tempol acid 10 plus alpha lipolic acid 10 mg/kgBW orally for one month (G5) shows mild mononuclear cell infiltration (lymphocytes and macrophages) and (M.N Cell) with moderate vacuolar degeneration × 40 H and E stain.