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The Role of Alpha Lipoic Acid and Tempol Against Liver Injury after Acetaminophen Subacute Exposure in Mice

The Role of Alpha Lipoic Acid and Tempol Against Liver Injury after Acetaminophen Subacute Exposure in Mice

Suhad Mohmmed Alrobyrai1 , Falah Muosa Al-Rekabi2*

1College of Veterinary Medicine, Iraq; 2University of Baghdad College of Veterinary Medicine Department of Physiology, Biochemistry and Pharmacology, Iraq.
 
*Correspondence | Falah Muosa Al-Rekabi, University of Baghdad College of Veterinary Medicine Department of Physiology, Biochemistry and Pharmacology, Iraq; Email: [email protected]

Figure 1:

The effect of orally administration APAP, Tempol, and Lipoic Acid for 30 days on body weight/g of male mice. Data= Mean±SEM, A-D significant (P < 0.05) differences between groups, a-c significant (P < 0.05) differences within groups, LSD of interaction=2.529

Figure 2:

The effect of orally administration APAP, Tempol and Lipoic Acid for 30 days on the serum activity of ALT (U/L) in experimental groups. Mean ± SEM, A-D significant (P <0.05) differences between groups, a-b significant (P <0.05) differences within groups, LSD of interaction=40.82.

Figure 3:

The effect of orally administration APAP, Tempol, and Lipoic Acid for 30 days on the GGT (U/L) in the experimental group. Mean ± SEM, A-D significant (P <0.05) differences between groups, a-b significant (P <0.05) differences within groups, LSD of interaction= 2.714.

Figure 4:

The effect of orally administration APAP, Tempol, and Lipoic Acid for 30 days on the PT/ sec in the Experimental group. Mean±SEM, A-D significant (P <0.05) differences between groups, a-b significant (P <0.05) differences within groups, LSD of interaction= 8.289.

Figure 5:

The effect of orally administration APAP, Tempol, and Lipoic Acid for 30 days on the INR in the experimental groups. Mean ± SEM, A-D significant (P <0.05) differences between groups, a-b significant (P <0.05) differences within groups, LSD of interaction= 7.175.

Figure 6:

Liver section of mice of C+ve group shows dilated central vein (C.V) with moderate mononuclear cell infiltration (lymphocytes and macrophages) with marked centrelobular necrosis (coagulative N.) × 40H and E stain.

Figure 7:

Liver section of mice treated by APAP 700 mg/kgBW and Tempol 20 mg/kgBW orally for one month (G3)shows severe mononuclear cell infiltration) lymphocytes and macrophages (with marked necrotic hepatocytes (coagulative N.)×40 H and E stain.

Figure 8:

Liver section of mice treated by APAP 700 mg/kgBW and alpha lipolic acid  20 mg/kgBW orally for  30 days (G4) shows central vein (C.V) with moderate mononuclear cell infiltration and  mild centrelobular necrosis (coagulative N.) × 40H and E stain.

Figure 9:

Liver section of mice treated by APAP 700 mg/kgBW and Tempol acid 10 plus alpha lipolic acid 10 mg/kgBW orally for one month (G5) shows mild mononuclear cell infiltration (lymphocytes and macrophages) and (M.N Cell) with moderate vacuolar degeneration × 40 H and E stain.

Advances in Animal and Veterinary Sciences

December

Vol. 12, Iss. 12, pp. 2301-2563

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