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Quercetin Improves Liver Function, Decreases the Expression of Pro-apoptotic Proteins p53 and Bax and Increases the Antioxidant Defense of Hepatocytes in Aged Male Rats

Quercetin Improves Liver Function, Decreases the Expression of Pro-apoptotic Proteins p53 and Bax and Increases the Antioxidant Defense of Hepatocytes in Aged Male Rats

Eman A. Al-Shahari1,2, Eman R. ElBealy3, Abdelhalim A. Alkhazendar4 and Abeer A. Alm-Eldeen4*

1Department of Biology, Faculty of Science and Arts, King Khaled University, Abha, Kingdom of Saudi Arabia
2Department of Biology, Faculty of Science, Ibb University, Ibb, Yemen 
3Biology Department, College of Science for Girls, King Khaled University, Abha, Kingdom of Saudi Arabia
4Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt
 
* Corresponding author: abeer.eldeen@science.tanta.edu.eg, abeer75875@hotmail.com

Fig. 1.

Effect of quercetin on the levels of AST, ALT, Albumin and plasma cholesterol in the rats that had 3 and 30 months old rats. Data are means ± SD with n=4, Different letters indicate significant differences among the columns (p ≤ 0.05).

Fig. 2.

Effect of quercetin on the liver MDA, SOD, CAT, GPx in the rats that had 3 and 30 months old. Data are means ± SD with n=4, Different letters indicate significant differences among the columns (p ≤ 0.05).

Fig. 3.

Effect of quercetin on liver of aged male rats. Histological structure of liver of 3 months old control rats (A), 3 months old treated liver (B), 30 months old saline treated rat (C) and 30 months old quercetin-treated rat (D). Note the vesicular nuclei (black arrows), cellular infiltration (**), dark nuclei (white arrow), vacuolated hepatocytes (black arrowhead) and congestion of the central vein (*). Stain: hematoxyline and eosin.

Fig. 4.

Immunostaining of histological sections of livers of rats with p53 antibodies. A, 3 months old control rats B, 3 months old quercetin-treated rats; C, 30 months old saline-treated rats; D, 30 months old quercetin-treated rats. Note the rarity of p53 expressions in A and B then the increase in its expression in C (arrows) then the rare of its expression in D.

Fig. 5.

IImmunostaining of histological sections of livers of rats with bax antibodies. A, 3 months old control rat; B, 3 months old quercetin-treated rats; C, 30 months old saline-treated rats; D, 30 months old quercetin-treated rats. Note the rarity of bax expressions (arrows) in A and B then the increase of its expression in C (arrows) then the decrease of its (arrows) expression in D.

Pakistan Journal of Zoology

October

Vol. 54, Iss. 5, Pages 2003-2500

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