Protective Effects of Arginine Against 4 Nitrophenol Induced Liver Injury in Rats
Protective Effects of Arginine Against 4 Nitrophenol Induced Liver Injury in Rats
Kai Wang, Weifeng Xu, Pengyuan Dai and Chunmei Li*
Effects of PNP and Arg exposure on histological observation of liver section. (A) Control+PBS group (CT) (B) Arg+PBS group (CTA) (C) Control+PNP group (PNP) (D) Arg+PNP group (PNPA). Liver sections of rats showed single arrow inflammatory infiltration, open arrow hepatic sinusoid damage, and filled arrow hepatic cells irregular arrangement scale bar=100 μm.
Effects of PNP and Arg exposure on serum. ALT activity (A), AST activity (B), and AKP activity (C). The statistical differences among groups were analyzed using a two-way analysis of variance (ANOVA) followed by Duncan’s multiple comparisons test. Bars represent the mean ± SEM. Differences between experimental groups were considered significant at p<0.05. (n=6).
Effects of PNP and Arg exposure on lipid peroxidation and antioxidative status in the liver. (A) H2O2 concentration, (B) T-SOD activity, (C) MDA concentration (D) CAT activity. For statistical details see Fig. 2.
Effects of PNP and Arg exposure on the expression of Nrf2 and regulated genes in the liver. (A) Nrf2 mRNA (B) HO-1 mRNA (C) NQO1 mRNA. All data were represented as the mean ± SEM from 6 rats per group. For statistical details see Fig. 2.
