Prevalence of Cytomegalovirus Infection among Children with and with out Autism in Jakarta, Indonesia
Prevalence of Cytomegalovirus Infection among Children with and with out Autism in Jakarta, Indonesia
Isti Anindya1, Ibnu Agus Ariyanto2 and Amin Soebandrio2
ABSTRACT
Cytomegalovirus (CMV) can affect the structural development and functional connectivity of the brain in children with autism. The infection in healthy children is usually mild or asymptomatic, but individuals with weakened immune systems are at higher risk for severe diseases. Study in Egypt showed a high prevalence of CMV IgG (97.8%) in children with autism. In Indonesia, there is no current data available to indicate the prevalence of CMV in children with autism. Therefore, we examined anti-CMV IgG in children with autism and analyzed the relationship between IgG CMV variable and more independent variables. During 2023, 100 children with autism and 101 children without autism (2-5 years old) were offered a CMV antibody test used ELISA (Enzyme-Linked Immunosorbent Assay). Besides of anti-CMV IgG, gender, age in children, we also assessed other parental variables and used linear regression. Seropositivity of CMV in children was found to be 98% (with autism) and 96% (without autism). We identified a strong relationship between IgG CMV (R2 = 0.041) and children gender (autism group). However, no other statistically significant variable was identified. Taken together, CMV infection in autism had high prevalence (98%) and have relationship with children gender in children with autism group. We found no additional and statistically significant varibles in children without autism group.
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