Possible Antiproliferative Effect of Tolfenamic Acid on Human LNCaP Prostate Cancer Cell Lines
Possible Antiproliferative Effect of Tolfenamic Acid on Human LNCaP Prostate Cancer Cell Lines
Rıfat Ertekin1*, Mete Ozkurt1, Gokhan Kus2 and Selda Kabadere1
The effects of TA application in doses of 1, 5, 10, 25, 50 and 100 μM at 24th and 48th h upon LNCaP cell survival. Compared to control group, the results are: **, p < 0.01; ***, p < 0.001.
Determination of cell percentage of early apoptosis in cancerous LNCaP cells following TA application (A, Control; B, 25 μM; C, 50 μM; D, 100 μM) for 24 h with LNCaP with the flow cytometric method. Live cells FITC (-) / PI (-), early apoptotic cells (FITC (+) / PI (-), necrotic or late apoptotic cells FITC (+) / PI (+).
Determination of cell percentage of early apoptosis in cancerous LNCaP cells following TA application (A, Control; B, 25 μM; C, 50 μM; D, 100 μM) for 48 h with LNCaP. Live cells FITC (-) / PI(-), early apoptotic cells (FITC (+) / PI (-), necrotic or late apoptotic cells FITC (+) / PI (+).
