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Polymorphisms within CEBPA, PRKAG3 and SREBF1 Genes Associated with Fat Deposition in Fat-tail Altay Sheep

Polymorphisms within CEBPA, PRKAG3 and SREBF1 Genes Associated with Fat Deposition in Fat-tail Altay Sheep

Guangming Xiang1, Ran Di1, Yaowu Wang1, Shangquan Gan2, Shouren Liu2, Xiangyu Wang1, Wenping Hu1, Qiuyue Liu1* and Mingxing Chu1*

1Key Laboratory of Animal Genetics and Breeding and Reproduction of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China
2State Key Laboratory of Sheep Genetic Improvement and Healthy Production, Xinjiang Academy of Agricultural and Reclamation Sciences, Shihezi, 832000, PR China
 
* Corresponding author: liuqiuyue@caas.cn; mxchu@263.net

ABSTRACT

The fat tail/rump is considered as an adaptive selection under harsh challenges which serves as a fat store for the animal. However, the mechanism of fat deposition in tail is unclear. The polymorphisms of candidate sheep CEBPA, PRKAG3 and SREBF1 genes and their relationship with fat deposition between fat-tailed (rumped) and thin-tailed breeds were investigated. Two and one SNPs were identified for PRKAG3 and SREBF1 respectively. Genotyping method was used to analyze genotypes among Altay sheep (fat-rumped breed) and White Suffolk (thin-tailed breed) by Sequenom MassArray. For PRKAG3 gene, a c.1744C>T SNP and a c.1840C>T SNP have been genotyped. For SREBF1 gene, an unknown synonymous c.2878A>G SNP was detected. The genotype distributions in those two loci were significantly different between fat tail and thin tail breeds by chi-square test (P<0.05).

 

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Pakistan Journal of Zoology

August

Vol. 54, Iss. 4, Pages 1501-2001

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