Pioglitazone Ameliorates Hypertension Induced Cardiac Hypertrophy and Down Regulates Cardiac Hypoxia Inducible Factor-l α in Rats
Pioglitazone Ameliorates Hypertension Induced Cardiac Hypertrophy and Down Regulates Cardiac Hypoxia Inducible Factor-l α in Rats
You-Ming Teng, Wen-Zhou Liu and Li Yang*
Fig. 1.
Effects of pioglitazone on myocardial structure in rats. (A) Control group, (B) Model group, (C) Pioglitazone (5 mg/kg) group, (D) Pioglitazone (10 mg/kg) group.
Fig. 2.
Effects of pioglitazone on myocardial fibrosis in rats. (A) Control group, (B) Model group, (C) Pioglitazone (5 mg/kg) group, (D) Pioglitazone (10 mg/kg) group.
Fig. 3.
Effects of pioglitazone on the levels of serum cytokine. (A) Ang II, (B) FFA. ** p < 0.01 compared to Control group. # p < 0.05, ## p < 0.01 compared to Model group.
Fig. 4.
Effects of pioglitazone on expressions the HIF-1α, PPARα, CPT-1 and PDK-4 mRNA expression. ** p < 0.01 compared to Control group. # p < 0.05, ## p < 0.01 compared to Model group.
Fig. 5.
Effects of pioglitazone on myocardial HIF-1α, PPARα, CPT-1 and PDK-4 protein expression. **** p < 0.0001, *** p < 0.001 compared to Control group. ## p < 0.01, ### p < 0.001 compared to Model group.
August 2023
Vol. 55, Iss. 4, Pages 1501-2000
