PPRV-Induced Immunosuppression at the Interface of Virus-Host Interaction
PPRV-Induced Immunosuppression at the Interface of Virus-Host Interaction
Jose M. Rojas, Noemi Sevilla and Veronica Martin
ABSTRACT
Peste des petits ruminants virus (PPRV) is the causal agent of a highly contagious disease that affects domestic and wild small ruminants, Peste des petits ruminants (PPR). Due to the important economical losses caused by this virus in Africa and Asia, the development of more effective, targeted and successful treatments for the disease are necessary. Like other Morbilliviruses, PPRV induces a suppression of the immune system during the acute disease, which favours the establishment and exacerbates the progression of secondary infections. This review gives an overview of the known immunosuppressive strategies of PPRV, among the Paramyxoviruses, as well as the strategies developed by this virus to evade the immune system, focusing on the newly identified factors involved. In the last years substantial progress has been reported in the identification of viral factors involved in the host immunosuppression, although future studies employing in vivo infection models are needed to clearly understand the mechanisms developed by these viruses, in particular PPRV, to interact with the host immune system. A better comprehension of this behaviour could lead the global strategy for the control and eradicaton of PPR, initiated by Food and Agriculture Organization of the United Nations (FAO) and World Organisation for Animal Health (OIE) on 2015.
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