Submit or Track your Manuscript LOG-IN

Oviductus Ranae Improves Cognitive Disorder and Suppresses Oxidative Stress in Aging Mice by Activating Nrf2 Pathway

Oviductus Ranae Improves Cognitive Disorder and Suppresses Oxidative Stress in Aging Mice by Activating Nrf2 Pathway

Yuechen Li1, Yumo Li1, Xuefeng Zhuang1, Guangfu Lv2, Xiaowei Huang1, Zhe Lin1, Yuchen Wang1* and He Lin1*

1College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China
2Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China
 
* Corresponding author: scarwyc@163.com, linhe@ccucm.edu.cn

Fig. 1.

The effect of OR on the cognitive impairments in aging mice. (A) the escape latency and (B) the distance in the target. Notes: Compared with the young mice group, #P<0.05; compared with the aging mice group, *P<0.05.

Fig. 2.

The effect of OR on oxidative stress in the hippocampus of aging mice. Activities of brain (A) SOD and (B) GSH-PX, (C) content of brain MDA, (D) activitys of brain MAO-B, (E) content of brain Lipo. Compared with the young mice group, #P<0.05; compared with the aging mice group, *P<0.05, **P<0.01.

Fig. 3.

The effect of OR on immune factors of aging mice. Content of serum (A) IgA, (B) IgG, (C) IgM, (D) IL-1 and (E) IL-2. Compared with the young mice group, #P<0.05; compared with the aging mice group, *P<0.05, **P<0.01.

Fig. 4.

The effect of OR on the Nrf2 pathway in aging mice. Nrf2, HO-1 and NQO1 expression were analyzed by western blot (A), Quantification graphs of Nrf2, HO-1 and NQO1 are shown on (B), (C) and (D). Compared with the young mice group, #P<0.05; compared with the aging mice group, **P<0.01.

Pakistan Journal of Zoology

October

Vol. 54, Iss. 5, Pages 2003-2500

Featuring

Click here for more

Subscribe Today

Receive free updates on new articles, opportunities and benefits


Subscribe Unsubscribe