Non-Monotonic Endocrine-Disrupting Effects of Bisphenol-A on Vitellogenin Expression in Juvenile Freshwater Cyprinid, Catla catla
Non-Monotonic Endocrine-Disrupting Effects of Bisphenol-A on Vitellogenin Expression in Juvenile Freshwater Cyprinid, Catla catla
Mehwish Faheem1,*, Saba Khaliq2 and Khalid Parvez Lone2
ABSTRACT
Endocrine-disrupting chemicals e.g. bisphenol-A can alter fish reproduction. Vitellogenin (vtg) is the egg yolk precursor and used as a biomarker for estrogenic endocrine disruption. To elucidate the endocrine-disrupting effect of bisphenol-A, juvenile Catla catla was exposed to graded concentrations of bisphenol-A (10,100,1000μg/l) for 14 days. BPA exposure strongly elevates vtg mRNA level in fish exposed to 100μg/l but at 1000 μg/l exposure of BPA, vtg level decreased compared to 100µg/l exposed fish. These results showed that BPA has estrogenic action and cause endocrine disruption in juvenile C. catla at environmentally relevant concentration. Moreover, these results also depict the non-monotonic, biphasic dose response to BPA.
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August 2017
Vol. 49, Iss. 4, Pages 1151-1546
