Salvia Miltiorrhiza Reinstates Growth Plate Width, Reduces Liver Oxidative Stress and Toxicity in Avian Tibial Dyschondroplasia
Salvia Miltiorrhiza Reinstates Growth Plate Width, Reduces Liver Oxidative Stress and Toxicity in Avian Tibial Dyschondroplasia
Fazul Nabi1,2, Hui Zhang1, Muhammad Kashif Iqbal1 , Mujeeb ur Rehman1, Muhammad Shahzad3, Khalid Mehmood1,3 and Jiakui Li1,*
Effects of SM on lameness and growth-plate morphology. Control group of birds showing normal posture with normal growth plate, Thiram fed birds showing lameness and enlarged growth plate width in the chicks with tibial dyschondroplasia (TD). SM group showing restored lameness and growth plate size by Salvia miltiorrhiza (SM) treatment. AC, Articular cartilage; TDL, TD lesion; GP, growth plate.
Effect of thiram and Salvia miltiorrhiza (SM) therapy on serum AST, ALT, ALP activity (A-C) and antioxidant biomarkers (SOD, GSH-Px) and MDA content (D-F). Thiram caused decrease in serum ALP activity and increase in ALT and AST contents. SM therapy caused an increase in ALP levels with a decrease in serum ALT and AST levels (A-C). The antioxidants SOD and GSH-Px were decreased while the MDA content was increased in thiram-fed group. SM therapy restored and increased antioxidant markers (SOD and GSH-Px) with a decrease in MDA contents (D-F). The data are expressed as the mean ± SD *P<0.05 among groups (n=10/group).
