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Liver Metabolism Adaptation to High-Concentrate Diet-Induced Milk Fat Depression

Liver Metabolism Adaptation to High-Concentrate Diet-Induced Milk Fat Depression

Lin Li1,2, Pingsheng Ye1, Xi Chen1, Shuping Yan1 and Yuanshu Zhang1*

1Key Laboratory of Animal Physiology and Biochemistry, Ministry of Agriculture, Nanjing Agricultural University, PR China 
2School of Biological Science and Engineering, Xingtai University, Xingtai 054001, China
 
* Corresponding author: yszhang1962@163.com

ABSTRACT

The high concentrate/low forage (HC/LF) diets cause a dramatic decline in milk fat secretion. Hepatic lipid metabolism is active when ruminant is on lactation period. The aim of this study was to evaluate liver metabolism adaptation to high-concentrate diet-induced milk fat depression (MFD). Six Saanen dairy goats were randomly divided into 2 groups and fed either a high-forage (HF) diet or a high- concentrate (HC) diet. The high-concentrate diet caused lower milk fat content and milk fat yield, namely induced MFD. While, the net hepatic TG production (portal vein - hepatic vein) significant increase in the HC group (P<0.01) and it was positive value. The net hepatic glucose, cholesterol and BHBA productions (portal vein - hepatic vein) were all negative values in the HC group. Expression of hepatic PC and PEPCK mRNA were up-regulated in HC group but had no significant effect (P>0.05). The mRNA expression of hepatic HMGCS2 significantly increased (P< 0.01) in HC group. The high concentrate feeding induced MFD, while fatty acids uptake into liver were stored as TG or incompletely oxidized to ketone body, the excessive consumption of fatty acids reduced the precursors of milk fat synthesis and finally decreased the milk fat content.

 

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Pakistan Journal of Zoology

October

Vol. 54, Iss. 5, Pages 2003-2500

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