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Interference of Maternal Derived Immunity Against Vaccination with Baculovirus H5 and ND Inactivated Vaccine

Interference of Maternal Derived Immunity Against Vaccination with Baculovirus H5 and ND Inactivated Vaccine

Mahmoud Said1*, Abd El Satar Arafa1, Mohammed A. Rohaim2* and Hussein A. Hussein2

1Reference Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, Giza (AHRI), Egypt; 2Faculty of veterinary medicine-Cairo university, Egypt.


Newcastle disease virus (NDV) and avian influenza viruses (AIVs) H5N1 are endemic in Egypt and extensive vaccinations are being applied for chicken flocks, which have maternal derived antibodies (MDA) for these viruses. To understand the interference of maternal derived immunity impact of maternal derived immunity interference in vaccination regimen in poultry, a total of one hundred day old commercial broiler chicks were vaccinated with LaSota. A group of chicks (n=40) were immunized using baculovirus (H5 and ND) inactivated vaccine via subcutaneous route. Birds (n=20) were then either challenged with 106 EID50 using Egyptian avian influenza H5N1 and Newcastle disease genotype VII. Comparative blood profiling in vaccinated and challenged, non-vaccinated and non-challenged and non-vaccinated and challenged indicated that MDA for H5N1 gradually decreased from 5.1 to 0.4 log2 and disappeared with in a month. While MDA for NDV remained 2.1 log2 until 28th day of age, the Geometric mean titers (GMT) for H5 were increased from the 7th day of age using both antigens (RE-5 antigen) and (S75/Egy/2015 antigen). Generally, GMT post-challenge was increased as the chicks overcome the infections. In conclusion, our results indicate that vaccination at 5th day old with baculovirus H5+ND inactivated vaccine can interfere with MDA of H5 vaccine and has negative impact on H5 vaccine titer. However, NDV titer remained unaffected under same experimental conditions. These findings highlight the need of country or region specific optimization of vaccination schedules for viral infections to obtain optimized vaccine-induced protections.

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Hosts and Viruses


Vol.10, Pages 1-71


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