In Silico Docking of Influenza-Interleukin 6 Interactions and the Role of HDAC-6 in its Modelling
In Silico Docking of Influenza-Interleukin 6 Interactions and the Role of HDAC-6 in its Modelling
Sandeep Satapathy and Rupam Ghosh
ABSTRACT
Influenza virus infections have been seen to be persistent throughout the year seasonally claiming several lives. IL-6/IL-2 receptors have been identified as crucial mediators for clearance of influenza by up regulating several intracellular defense mechanisms. Associated with IL-6 signalling is the expression acceleration of sequestrome 1(SQSTM1) / aggrosome and colocalization of HDAC6 to the cytoplasm. The key player HDAC6 is investigated for modelling several intracellular processes that come into action to bring out the viral clearance. The shuttling of HDAC6 takes place from nucleus to cytoplasm and vice versa controlling the overexpression of IFN-beta and ISGs which subsequently triggers virus specific immune response.
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