In Silico Analyses of the Pseudogenes of Helicobacter pylori
In Silico Analyses of the Pseudogenes of Helicobacter pylori
Neenish Rana, Nosheen Ehsan, Awais Ihsan and Farrukh Jamil*
ABSTRACT
Pseudogenes were previously regarded as molecular fossils, non-functional by-products of genome evolution. However, it has been indicated by several lines of evidences that some pseudogenes are active. Using current data of NCBI we have retrieved 65 pseudogenes from the genome sequence of human pathogenic bacteria Helicobacter pylori (H. pylori) strain 26695. Computational analysis of the genome showed 6 transcriptionally active pseudogenes that can produce stable mRNA secondary structure compared to their functional parents. Moreover it was observed that their putative protein products will be thermodynamically stable. The sequence-based predictions suggested that the pseudogenes-derived proteins may involve in different biological functions like translation, energy metabolism, amino acid metabolism and transport and binding.
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August 2017
Vol. 49, Iss. 4, Pages 1151-1546
