Improvements in Some Physiological and Histologic Aspects in the Rat Model When Lipoic Acid is Combined with Salbutamol
Improvements in Some Physiological and Histologic Aspects in the Rat Model When Lipoic Acid is Combined with Salbutamol
Huda K. Khassaf1*, Zainab A.H. Al-Mousawi1, Sawsan A. Ali2, Anwar Nather Seiwan3
ABSTRACT
This rat model study investigated the effects of alpha-lipoic acid (ALA) and salbutamol (SAL) on many blood thyroid hormones and electrolytes. A total of forty rats, weighing between 200-250 g at the beginning, were divided into three experimental groups at random: the control group, the SAL group which was given (80 mg/kg) of SAL orally for two days, and SAL plus ALA groups which was given (80 mg/kg) of SAL orally for two days, followed by 20 mg/kg of oral ALA for 28 days. The levels of the hormones TSH, T4, free T3 and free T4 were estimated. Also, total bilirubin (TB), Na+, K+, CL- and Ca+2 were measured. A statistical analysis of the thyroid gland tissue’s histological alterations was conducted. According to the findings, rats that got both SAL and ALA had higher levels of serum thyroxin T4, Free T3, and Free T4 than rats that did not get alA (p≤0.05). As well as decreased total bilirubin, Na+, and Ca+2 levels and increased K+ and Cl- levels (p≤0.05). Furthermore, ALA is an effective therapeutic medication that improves the histological characteristics of the thyroid gland noticeably. The results of this study indicated that supplementing with ALA improved blood thyroid profiles more than SAL did, and that this may have the ability to prevent unwanted side effects.
Keywords | Alpha-lipoic acid, Salbutamol, Thyroid hormones, Histology, Rats
To share on other social networks, click on any share button. What are these?
May 2024
Vol. 12, Iss. 5, pp. 802-993
