Importance and concept of resistance versus tolerance in biofilm mode of bacterial proliferation
Importance and concept of resistance versus tolerance in biofilm mode of bacterial proliferation
MALIK ASIF HUSSAIN
ABSTRACT
Biofilms play an important role in the pathogenesis of many
microorganisms. A number of animal and clinical studies have presented
importance and role of biofilms in various clinical conditions. This form of
growth enables them to grow in form of microbial communities, which
help them to grow and survive better. Resistance to antibiotics is usually
linked and described as a reason for better survival of microbes in
biofilms. In fact, it is not resistance to antibiotics in majority of cases;
rather it is ―tolerance‖ of these biofilm communities against antimicrobials.
The layers of biofilm provide a protective cover around bacteria and
hinder penetration of these agents deep. Furthermore, this tolerance also
helps them to survive against immune system, as immune system cells
and other components cannot penetrate through layers of biofilm. This
review paper discusses important aspects of biofilm formation, clinical
importance and the concept of resistance versus tolerance.
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June 2020
Vol.66, Iss. 1, Pages 1-126
