Immune Response to a Live Attenuated Chicken Anemia Virus (CAV) Vaccine. The Absence of Virus Shedding
Immune Response to a Live Attenuated Chicken Anemia Virus (CAV) Vaccine. The Absence of Virus Shedding
*Hanan M.M. Elzahed, Abd EL-Moneim A.A, *Afaf A. Khedr, *Elham A. Elabiare, Waleed S. Abd El-Latif, Reda M.I.
ABSTRACT
An assessment of the performance of a live attenuated (CAV) vaccine following administration to broiler breeder hens in eight houses at Il weeks of age. Antibodies to (CAV) in adult hens and maternally derived antibodies to (CAV) in progeny chicks were assayed by ELISA. Vaccinated dams showed a high level of antibody -to (CAV) followed by moderate level for up to 50 weeks of age. In addition progeny chicks showed a detectable level Of maternally-derived antibody. New castle Disease Virus (NDV) antibodies were monitored in adult hens during the first 22 weeks of their age using Haemagglutination inhibition (HI) technique. Dams showed sufficient of antibodies to (NDV) through this period indicating that the vaccinated hens were immunopotent. No sign of immunosuppression in progeny chicks was detected by measuring (NDV) HI antibody titers pre and post lasota vaccination and by vaccination challenge experiment, more over no (CAV) shedding was observed in progeny chicks at early stage of breeding period. In this stage CAV shedding was recorded to be most using CAV VPI PCR assay. These results support the evidence that vaccination of breeders flock with the live attenuated (CAV) vaccine could be an effective means of control of chicken anemia virus induced clinical disease.
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