Identification of Antibiotic Resistance Genes in Staphylococcus aureus Isolated from Animals with Ocular Infection
Identification of Antibiotic Resistance Genes in Staphylococcus aureus Isolated from Animals with Ocular Infection
Karar Ali Abdulkhuder* and Abdul Kareem Salman Alyassari
ABSTRACT
Antibiotic resistance poses a significant challenge in the management of Staphylococcus aureus infections, particularly those affecting the eyes. Understanding the antibiotic susceptibility profiles and genetic mechanisms underlying resistance is crucial for guiding effective treatment strategies. This study aimed to assess the antibiotic susceptibility patterns and molecular characteristics of Staphylococcus aureus strains isolated from eye infections. For this purpose, a total of 20 Staphylococcus aureus isolates were obtained from eye infection samples and then were subjected to antibiotic susceptibility testing using standard methods. Additionally, a subset of isolates demonstrating high resistance was selected for molecular analysis to detect the presence of antibiotic resistance genes, including mecA, ermA, and ermB. The antibiotic susceptibility testing revealed varying degrees of effectiveness among the antibiotics tested. Notably, mecA, ermA, and ermB genes were detected in all samples analyzed, indicating widespread methicillin and macrolide resistance. These findings underscore the complex nature of antibiotic resistance among Staphylococcus aureus strains causing eye infections, indicating the failure of antibiotic efficacies in these infections.
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