IMMUNOLOGICAL STUDIES OF COMBINED FOOT AND MOUTH DISEASE AND RIFT VALLEY FEVER OIL VACCINE
IMMUNOLOGICAL STUDIES OF COMBINED FOOT AND MOUTH DISEASE AND RIFT VALLEY FEVER OIL VACCINE
Walaa ,S. Shabanaa;Bakr, A. Abdallaa; Eman, M. ELShalamia; I.M. Redab; M. A. Shalabyb
ABSTRACT
Foot-and-mouth disease (FMD) is an economically important disease of cloven-hoofed animals.
In Egypt, FMD assumes as enzootic form and attacks susceptible animals causing high losses in milk
and meat production. Rift valley fever virus causes serious and fatal disease in animals and man. It
produces high abortion rate among pregnant ewes and cows, causes heavy mortalities in young
lambs and calves. In the present study the Montanide ISA 50 oil adjuvanted combined FMD/RVF
vaccine was tested in sheep and compares it with single vaccines either FMD or RFV alone.The
mean of antibody titers continued with the protective level till the 32 to 36th week post vaccination,
In single vaccination either FMD or RFV alone while till to 40th WPV in combined FMD/RVF
vaccine.In the final we can conclude that the use of Montanide ISA 50 as an oil adjuvant in prepared
vaccines improve the immune response against FMD and RVF, giving high titer of antibodies
against both diseases, and long duration of immunity in combined FMD/RVF vaccines.
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December 2013
Vol. 10, Pages 1-171
