Hepato Renal Protective Effect of Origanum Majorana against Adverse Effect of Ivermectin in Rabbits
Hepato Renal Protective Effect of Origanum Majorana against Adverse Effect of Ivermectin in Rabbits
Ahmed Mohamed Elmahdy1*, Naglaa Mohammed Alkalamawy2
Renal tissue of Ivermectin treated group revealed; moderate dilation of peri- glomerular space, fragmentation and even degeneration of some glomerular tufts. H&E X 400.
Renal tissue of Ivermectin-origanium treated group revealed; dilation of peri-glomerular space, H&E X 400.
PECAM-1 expression showing; normal pattern of expression in both of glomerular tufts and tubular epithelia in control negative group 1a and group 2b. Loss of expression in both glomerular tufts and Tubular epithelia in Ivermectin treated group (group 3c) and significant restoration of expression in group 4d. HRP/ PECAM-1 X 400.
Hepatic parenchyma of group 2 revealed mild hydropic degeneration of hepatocytes associated with dilation of hepatic sinusoids (in some areas). H&E X 400.
Hepatic parenchyma of group 3 revealed marked dilation of hepatic sinusoids associated with distortion of hepatic cords and fibrosis of portal area. H&E X 400.
Hepatic parenchyma of group 4 revealed dilation of hepatic sinusoids associated with preservation of hepatic cords integrity. H&E X 400.
PECAM-1 expression showing; absence of expression in control negative group (a), minute expression of some dilated hepatic sinusoids, in group 2 (b), intense expression in Invermectin group (c), and weak expression at the margin of dilated hepatic sinusoids in Ivermectin- O.M. treated group (d). HRP/ PECAM-1 X 400.
