Heat Shock Proteins and Cytochrome P450 1a1 Expression as Biomarkers of Exposure to Bisphenol A in Catla catla
Heat Shock Proteins and Cytochrome P450 1a1 Expression as Biomarkers of Exposure to Bisphenol A in Catla catla
Mehwish Faheem1*, Maleeha Rafeeq1, Aisha Majeed1 and Saba Khaliq2
ABSTRACT
Biomarkers are extensively used to evaluate the early adverse effects of a toxicant exposure in an organism. Freshwater is exposed to many anthropogenic compounds that adversely affect aquatic life especially, fish population. Effect of acute exposure of low concentrations of BPA (10, 100, 1000 µg/l) on liver cyp1a1 and heat shock proteins mRNA level was evaluated using real time qPCR. Results revealed that exposure to bisphenol A caused decrease expression of cyp1a1 in a concentration dependent manner. Exposure to graded concentrations of bisphenol-A resulted in significant increase in mRNA expression of heat shock proteins (hsp70 and hsp90). In the light of present results, expression of cyp1a1 or heat shock proteins may be used as biomarkers to assess the presence of BPA in the environment.
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February 2020
Vol. 52, Iss. 1, Pages 1-424
