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Genome-Wide Association Study on Chinese Merino Sheep Alopecia

Genome-Wide Association Study on Chinese Merino Sheep Alopecia

Shudong Liu1,2, Shuai Wang1,2, Haoran Cui1 and Genyuan Chen1,2*

1College of Animal Science, Tarim University, Alar, Xinjiang, China
2Key Laboratory of Tarim Animal Husbandry Science and Technology, Xinjiang Production and Construction Corps, Alar, Xinjiang, China
 
* Corresponding author: cgygood2007@163.com

Fig. 1.

Manhattan plot of Chinese Merino sheep alopecia. The Manhattan plot shows nominal P-values from association with Merino sheep alopecia by chromosomal position. The top red line shows a genome-wide significance threshold defined by nominal P-values of 2.06x 10-7, which is P= 0.01/48335. The lower blue line shows a genome-wide suggestive significance threshold defined by nominal P-values of 1.03x 10-6, which is P= 0.05/48335.

Fig. 2.

Quantile-Quantile plot of Chinese Merino sheep alopecia. Quantile-quantile plots from association with Merino sheep alopecia, where the red line shows the expected distribution. Comparison of p-value distributions when all the 48335 analyzed Illumina SNPs were included. The expected –log 10 (p) is on the x-axis and the observed –log 10 (p) is on the y-axis.

Fig. 3.

Linkage disequilibrium of the OAR2_128282778.1 surrounding 5.4 Mb, which have 4 haplotype blocks. SNP pairs are coloured according to the standard Haploview colour scheme: D = 1, red; D’<1, other colours. LOD>2 and D’ = 1, red; LOD>2 and D’ <1, shades of pink/red; LOD <2 and D’ = 1, blue; LOD <2 and D’<1, white (LOD is the log of the likelihood odds ratio, a measure of confidence in the value of D’).

Fig. 4.

Linkage disequilibrium of the OAR2_128282778.1 surrounding 5.4 Mb, which have 4 haplotype blocks. SNP pairs are coloured according to the standard Haploview colour scheme: D = 1, red; D’<1, other colours. LOD>2 and D’ = 1, red; LOD>2 and D’ <1, shades of pink/red; LOD <2 and D’ = 1, blue; LOD <2 and D’<1, white (LOD is the log of the likelihood odds ratio, a measure of confidence in the value of D’).

Pakistan Journal of Zoology

February

Pakistan J. Zool., Vol. 56, Iss. 1, pp. 01-501

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