British Journal of Virology
Souvik Ghosh, Nobumichi Kobayashi
Group A rotaviruses (RVA) are a major cause of severe viral diarrhea in infants and children. Although studies on the genetic diversity of the antigenically important RVA VP7- and VP4- protein encoding genes are important for vaccine development or judging the efficacy of existing RVA vaccines, they do not always provide conclusive information on the overall and complex genetic makeup of RVAs, as the remaining 9 RVA gene segments are also susceptible to the forces governing RVA genetic diversity. Whole genomic analysis of RVAs has revolutionized the study of RVA genomics, providing a plethora of conclusive and vital data on the overall genetic diversity, true origin and complex evolutionary patterns of human RVA strains. In this review, we have summarized and discussed the significance of recent research outcomes obtained from whole genomic analysis of common and unusual human RVAs.