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Genetic Characterization of Pigeon Paramyxovirus Type 1 in Egypt

Genetic Characterization of Pigeon Paramyxovirus Type 1 in Egypt

Mohammed A. Rohaim1*, Rania F. El Naggar2, Ahmed M. Helal3, Hussein Ahmed Hussein1 and Neil LeBlanc4

1Department of Virology, Faculty of Veterinary Medicine, Cairo University, Egypt; 2Department of Virology, Faculty of Veterinary Medicine, University of Sadat City, Egypt; 3Central Laboratory for Evaluation of Veterinary Biologics, Egypt; 4The Pirbright Institute, Ash Road, Pirbright, Woking, GU24 0NF, United Kingdom.

ABSTRACT

This study reports the first pathotypic and genetic characterizations of the pigeon paramyxovirus type I (PPMV-1) from pigeon in Egypt during 2014. Pathotyping, based on the mean death time (86 hours) in eggs and the intracerebral pathogenicity index (1.2), and the amino acid motif, (112KRQKR116), at the cleavage site of the fusion (F) protein indicated the emergence of PPMV-1 in Egypt. Phylogenetic analysis of the F and haemagglutinin-neuraminidase (HN) genes indicated that the isolate clustered with the PPMV-1 strains recently reported from Israel within subgenotype VIb. Our findings report the emergence of PPMV-1 in Egyptian pigeons and the potential role these wild birds can play in the transmission and evolution dynamics of PPMV-1.

 

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Hosts and Viruses

December

Vol. 7, Iss. 6, Pages 129-146

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