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Fibrobronchoscope-Assisted Lavage Combined with Azithromycin in Regulating the Lung Function and Th17/Treg of Peripheral Blood in Children with Mycoplasma pneumoniae Pneumonia

Fibrobronchoscope-Assisted Lavage Combined with Azithromycin in Regulating the Lung Function and Th17/Treg of Peripheral Blood in Children with Mycoplasma pneumoniae Pneumonia

Hui Xu1,*, Ronghua Luo1, Yaping Duan1, Mingjia Chen1, Jiaxu Zhou1 and Xiaoli Shao2

1Department of Pediatric Respiratory Medicine, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610000, China
2Department of Pediatrics, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China
 
* Corresponding author: xh15184465671@163.com

ABSTRACT

The objective of this study was to investigate the role of bronchofiberoscope-assisted lavage combined with azithromycin in regulating the pulmonary function and Th17/Treg of peripheral blood in children with Mycoplasma pneumoniae pneumonia (MPP). From January 2018 to January 2020, 114 children with MPP in our hospital were selected and randomly divided into control group and experimental group, each containing 57 cases. The control group was given azithromycin. The experimental group was given fibrobronchoscope-assisted lavage on the basis of the control group. The curative effect, the time of remission of clinical symptoms (pulmonary rales, body temperature, cough), hospital stay, and adverse reactions, lung function [the forced expiratory volume in the first second as a percentage of the predicted value (FEV1%), tidal volume (V-T), forced expiratory volume in the first second (FEV1), forced vital capacity (FVC)], peripheral blood Th17, Treg, Th17/Treg cells, soluble B7 homolog 3 (sB7-H3), galectin 3 (Gal-3), and lung surfactant protein A (SP-A) before and after treatment were evaluated between the two groups. The total effective rate of treatment in the experimental group was higher than that in the control group (P<0.05); the cough relief time and hospitalization time of the experimental group were shorter than those of the control group (P<0.05); after treatment, FEV1%, V-T, FEV1, and FVC in the experimental group were higher than those in the control group (P<0.05); after treatment, the levels of Th17 and Th17/Treg cells in the peripheral blood of the experimental group were lower than those of the control group, and the levels of Treg cells were higher than that of the control group (P<0.05); after treatment, the peripheral blood sB7-H3, Gal-3, SP-A levels of the experimental group were lower than those of the control group (P<0.05); there was no significant difference in adverse reactions between the two groups (P>0.05). To conclude, Fibrobronchoscope-assisted lavage combined with azithromycin in the treatment of children with MPP can regulate the expression of Th17/Treg and sB7-H3, Gal-3, SP-A in peripheral blood, promote the improvement of clinical symptoms, improve lung function. 

 

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Pakistan Journal of Zoology

October

Vol. 54, Iss. 5, Pages 2003-2500

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