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Feeding a High-Concentrate Diet Reduces Milk Production is Associated with Endogenous Growth Hormone in Lactating Goats

Feeding a High-Concentrate Diet Reduces Milk Production is Associated with Endogenous Growth Hormone in Lactating Goats

Ping Sheng Ye1, Lin Li2, Yu Long Wu3 and Yuan Shu Zhang1*

1Key Laboratory of Animal Physiology and Biochemistry, Ministry of Agriculture, Nanjing Agricultural University, PR China
2School of Biological Science and Engineering, Xingtai University, Xingtai 054001, China
3The Food Science College, Nanjing Xiaozhuang University, PR China
 
* Corresponding author: yszhang1962@163.com

ABSTRACT

The aim of this work was to evaluate the effects of endogenous GH-IGF-1 axis on lactating goats fed with high-concentrate diets. Ten lactating goats were used and randomly divided into two groups, in a 2×2 Latin square experiment design with different forage to concentrate rations of 40:60 (the control group) and 60:40 (the high-concentrate group), respectively. During the experiment, milk samples were collected to assay the content of milk compositions; plasma samples were collected to measure the content of IGF-1 and GH. The liver and mammary gland samples were collected to observe the expression of IGF-1R and GH. The results showed that compared with the control group, the content of plasma GH and IGF-1 were decreased in the high-concentrate group, and the percentage of lactose and milk yield were also decreased. Meantime, the mRNA expression of IGF-1R in mammary gland was down-regulated in the high-concentrate group. Our results indicated that feeding with high-concentrate diets for 9 weeks would decrease the contents of endogenous GH and IGF-1, and eventually lead to the decreased milk yield.

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Pakistan Journal of Zoology

June

Pakistan J. Zool., Vol. 56, Iss. 3, pp. 1001-1500

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