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FK228 Ameliorates the Liver Toxicity and Oxidative Stress on Thiram-Induced Tibial Dyschondroplasia in Chicken

FK228 Ameliorates the Liver Toxicity and Oxidative Stress on Thiram-Induced Tibial Dyschondroplasia in Chicken

Muhammad Kashif Iqbal1*, Khalid Mehmood2,4, Shakeel Ahmed3, Fazul Nabi4, Muhammad Arif Rizwan1, Muhammad Kaleem1, Mushtaq Ahmed1, Abdul Waheed1 and Jiakui Li5

1Institute of Continuing Education and Extension, Cholistan University of Veterinary and Animal Sciences, Bahawalpur 63100, Pakistan.
2Department of Clinical Medicine and Surgery, Faculty of Veterinary and Animal Sciences, The Islamia University of Bahawalpur 63100, Pakistan.
3Instituto de Farmacia, Facultad de Ciencias, Universidad Austral de Chile, Campus Isla Teja 5090000, Valdivia.
4Faculty of Veterinary and Animal Science, Lasbela University of Agriculture, Water and Marine Science, Uthal, Balochistan
5Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, PR China.
 
* Corresponding author: mkashifiqbal@cuvas.edu.pk

Fig. 1.

The effect of FK228 on growth-plate width and morphology. Chicks and tibial growth plates were photographed on day 14. Control group with normal growth plate size, thiram-induced tibial dyschondroplasia (TD) group have increased growth plate width while FK228 group restored growth-plate size after treatment. GP, growth plate; TDL, TD lesion.

Fig. 2.

VEGF mRNA expression was analyzed by quantitative real time polymerase chain reaction (qRT-PCR) on day 10 and 14 in avian growth plate of normal, thiram, FK228 treated avian chicks. Data expressed in arbitrary units as the means±SE (n= 6 for each group). Control group set to one thus equivalent to the N-fold difference. a, b letters designate significant difference (P <0.05).

Fig. 3.

Gene expression of Flk-1A was analyzed by quantitative real time polymerase chain reaction (qRT-PCR) on day 10 and 14 in avian growth plate of normal, thiram, FK228 treated avian chicks. Data expressed in arbitrary units as the means ± SE (n = 6 for each group). Control group set to one thus equivalent to the N-fold difference. a, b, c letters designate significant difference (P <0.05).

Pakistan Journal of Zoology

October

Vol. 54, Iss. 5, Pages 2003-2500

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