Erlotinib and Garcinia Cambogia Prevent Adenine Induced Nephrotoxicity in Adult Male Albino Rats Through Modulating EKR1/2, STAT3, and p53 Apoptotic Pathways
Erlotinib and Garcinia Cambogia Prevent Adenine Induced Nephrotoxicity in Adult Male Albino Rats Through Modulating EKR1/2, STAT3, and p53 Apoptotic Pathways
Dalia M. Amin1*, Noha Mohammed Halloull1, Walaa E. Omar2, Basma A. Ibrahim2, Nahla M. Ibrahim1
Efect of garcinia cambogia and erlotinib administration on serum levels of (a) creatinine (b) blood urea nitrogen and, (c) uric acid in adenine induced nephrotoxicity in rats.
Efect of garcinia cambogia and erlotinib administration on renal levels of (a) Malondialdehyde (b) superoxide dismutase activity and, (c) catalase activity in adenine induced nephrotoxicity in rats.
Efect of garcinia cambogia and erlotinib administration on renal levels of (a) transforming growth factor (TGF)-β1, (b) phospho-signal transducer and activator of transcription (STAT)-3, (c) p-extracellular signalregulated kinase (ERK)-1/2 in adenine induced nephrotoxicity in rats
Kidney sections stained with Hematoxylin–eosin stain (×400) showing glomerulai (G), tubules (T) and tubular injury and infltration of infammatory cells (astriks). A: control group B: adenine group C: garcinia cambogia D: erlotinib group.
Efect of garcinia cambogia and erlotinib administration on kidney expression scores of B-cell lymphoma (Bcl)-2 in adenine induced nephrotoxicity in rats.
Efect of garcinia cambogia and erlotinib administration on kidney expression scores of tumor protein p-53 in adenine induced nephrotoxicity in rats.
Electron micrograph of a proximal tubule for kidney sections from A: control group (normal ultrastructure of cells) B: adenine group (Large irregular cytosomes contain large numerous myeloid bodies, mitochondria and cisternae of rough edoplasmic reticulum are swollen. Large vacuoles are present near the base of the cell) C: garcinia cambogia D: erlotinib group (both groups show the cell ultra structure is combarable to that of the control).
