Effects of cigarette smoking on serum proteins profile in male active and passive smokers
Effects of cigarette smoking on serum proteins profile in male active and passive smokers
Effects of cigarette smoking on serum proteins profile in male active and passive smokers
Nabila Roohi, Mehjabeen, Samina Ashraf*
ABSTRACT
The present study deals with the analysis of serum total proteins and fractions
(albumin, total globulins, gamma globulins and non-gamma globulins) of active and
passive smokers. Blood samples of 180 cigarette smokers were collected from
different locations of Lahore and 60 healthy non-smokers from University of the
Punjab, Quaid-e-Azam campus Lahore, in terms of comparable age, height, weight
and socioeconomic set up. Serum protein profile was analyzed using commercially
available kits by using automated clinical chemistry analyzer. Serum total proteins
have shown a significant decrease in smokers in comparison with controls. A
significant depression in serum albumin was observed in smokers due to increased
excretion of albumin in bound state with the chemicals, whereas, total globulins,
gamma globulins and non-gamma globulin serum proteins have shown significant
increase in smokers. Our findings provide primary information about fractions and
total serum proteins of cigarette smokers. The decrease in albumin justifies the
reduction in total serum proteins and elevation in globulins. Smoking cessation
plays a significant role in recovery of these proteins.
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