Effect of Quercetin on Cadmium-Induced PERK-CHOP Apoptosis Pathway in Rat Testis
Effect of Quercetin on Cadmium-Induced PERK-CHOP Apoptosis Pathway in Rat Testis
Bingzhao Yan1, Guiping Chen2, Lulu Ding1, Ruxue Huang1, Wenjing Yu1 and Jicang Wang1*
Fig. 1.
Histopathology of testicular sections from different groups (20×). Scale bar is 50 μm. (A) Control group; (B) CdCl2 group; (C) CdCl2 + Que group; (D) Que group. The orange arrow indicates the germinal epithelium and varicocele.
Fig. 2.
TUNEL assay for apoptosis in testicular tissue. Scale bar is 50 μm. The green ones are apoptotic cells (yellow arrows, 40×). (A) Control group; (B) CdCl2 group: (C) CdCl2 + Que group; (D) Que group.
Fig. 3.
Effects of Que on mRNA expression levels of GRP78, CHOP, ATF4, PERK, elF2a, Bax, and Bcl-2. Bars indicate mean ± SEM (n = 3).
Fig. 4.
Western blot target band gray image + indicates added cadmium or quercetin, and - indicates no addition.
December 2024
Pakistan J. Zool., Vol. 56, Iss. 6, pp. 2501-3000
