Effect of Autologous Multiple Bone Marrow Aspirate on the Healing of Metacarpal and Metatarsal Fractures Reduced by Internal Fixators in Beetal Goats
Effect of Autologous Multiple Bone Marrow Aspirate on the Healing of Metacarpal and Metatarsal Fractures Reduced by Internal Fixators in Beetal Goats
Abdul Asim Farooq1,2*, Muhammad Arif Khan1, Hamid Akbar1,
Muhammad Ashraf3, Saima Inayat4, Muhammad Usman Saleem5,
Saeed Murtaza2, Maqbool Hussain Shah2 and Muhammad Arshad Javid5
ABSTRACT
Fractures related to long bones in female Beetal goats fail to heal or show delayed healing that leads to intensified morbidity. Bone marrow aspirate (BMA) has been suggested as an efficient biological adjuvant for healing long bone fractures. BMA comprises bone mesenchymal stem cells. This study aims to assess the potential of autologous BMA on metacarpal and metatarsal fracture of Beetal goats presented at the surgery clinic of the University of Veterinary and Animal Sciences Lahore, Pakistan. Beetal goats were selected (n=20), and divided into four different groups. The first group was designated as bone plating with bone marrow aspirate (BPMA) in which fracture was reduced by using the bone plates along with the application of multiple BMA on days: 0, 14, 28, and 45. Furthermore, the second group was designated as bone plating with normal saline (BPNS) in which fracture was reduced by using the bone plates along with the application of normal saline. Additionally, the third group was designated as bone wiring with bone marrow aspirate (BWBM), and the fourth group, was bone wiring with normal saline (BWNS). Both third and fourth groups were treated with bone wiring along with BMA and bone wiring along with NS respectively. The rate of healing post-treatment was assessed by radiographic union score (RUS), weight-bearing score (WBS), and serobiochemical evaluations on days: 0, 7, 14, 28, and 45. Our data showed a significant difference in the healing of fractures treated with BMA as compared to NS on days; 7 and 14. Moreover, the RUS, WBS, and serobiochemical profiles of goats treated with BMA showed improved healing of fractures as compared to the goats treated with NS. In summary, we observed that the healing process of the metacarpal and metatarsal fractured bones was reduced by bone plating, and bone wiring was ameliorated with the application of multiple BMA. We proposed further studies on larger cohorts. BMA may be used as supportive therapy to enhance the healing process of fractures in goats.
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